Uranium-Induced DNA Damage
نویسندگان
چکیده
The goal of this project is to see if and how uranium (U) may contribute to DNA damage. Radioactive forms of uranium have been used as fuel for nuclear reactors and as fissionable material for atomic weapons, tank armor, and ammunition shells. People who work with or live near processed uranium have experienced higher incidence of lung cancer, which has been attributed to radon, a radioactive daughter product (gas) of uranium. The non-cancer effects of uranium itself (not radon), such as DNA damage (genotoxicity), are less well studied.
منابع مشابه
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Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...
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Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...
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